Table 1:
Baseline characteristics of Multi-Ethnic Study of Atherosclerosis participants stratified by race-specific Lp(a) quintiles
| Characteristics | Quintile 1 (N=898) |
Quintile 2 (N=904) |
Quintile 3 (N=904) |
Quintile 4 (N=905) |
Quintile 5 (N=901) |
p-value |
|---|---|---|---|---|---|---|
|
| ||||||
| Lipoprotein(a) range (mg/dl) | ||||||
| White | 0 – 4.6 | 4.7 – 9.8 | 9.9 – 17.1 | 17.2 – 38.2 | 38.5 – 236.3 | |
| Black | 0 – 16.6 | 16.7 – 28.6 | 28.7 – 42.5 | 42.6 – 72.7 | 73.0 – 314.2 | |
| Hispanic | 0 – 4.8 | 4.9 – 9.7 | 9.8 – 17.5 | 17.6 – 34.8 | 35.2 – 316.5 | |
| Chinese | 0 – 6.4 | 6.5 – 10.7 | 10.8 – 16.6 | 16.7 – 29.6 | 29.8 – 131.8 | |
| Median Lipoprotein(a) (mg/dl) | <0.01 | |||||
| White | 2.6 [1.4 – 3.6] | 7.2 [5.9 – 8.7] | 13.2 [11.3 – 14.9] | 24.0 [20.4 – 29.9] | 64.1 [50.2 – 85.3] | |
| Black | 10.4 [5.5 – 13.3] | 23.4 [20.5 – 25.9] | 35.2 [31.6 – 38.6] | 54.3 [47.7 – 61.7] | 94.8 [84.1 – 111.2] | |
| Hispanic | 2.5 [0.9 – 3.8] | 7.7 [6.3 – 8.6] | 13.1 [11.1 – 15.4] | 23.8 [20.2 – 29.3] | 63.2 [46.2 – 87.6] | |
| Chinese | 4.1 [2.5 - 5.1] | 8.7 [7.8 – 9.8] | 13.1 [11.9 – 14.9] | 21.2 [19.1 – 23.5] | 49.7 [36.5 – 72.4] | |
| Age (years) | 61.6 ± 10.6 | 61.9 ± 10.4 | 62.1 ± 10.0 | 62.1 ± 10.5 | 61.9 ± 10.4 | 0.52 |
| Men | 463 (51.6 %) | 449 (49.7 %) | 427 (47.2 %) | 434 (48.0 %) | 372 (41.3 %) | < 0.01 |
| Systolic BP (mm Hg) | 126.2 ± 20.6 | 126.3 ± 21.3 | 125.7 ± 21.7 | 126.7 ± 22.1 | 125.9 ± 21.2 | 0.67 |
| Diastolic BP (mm Hg) | 72.1 ± 10.0 | 72.3 ± 10.0 | 71.8 ± 10.7 | 72.3 ± 10.5 | 71.7 ± 10.3 | 0.37 |
| Antihypertensive use | 317 (35.3 %) | 302 (33.4 %) | 288 (31.9 %) | 279 (30.8 %) | 299 (33.2 %) | 0.17 |
| Diabetes | 93 (10.4 %) | 84 (9.3 %) | 84 (9.3 %) | 85 (9.4 %) | 83 (9.2 %) | 0.80 |
| Smoking | 113 (12.6 %) | 103 (11.4 %) | 133 (14.7 %) | 118 (13.0 %) | 112 (12.4 %) | 0.70 |
| Total cholesterol (mg/dL) | 186.7 ± 34.3 | 191.0 ± 32.2 | 195.5 ±33.4 | 197.4 ± 34.4 | 208.2 ± 35.4 | < 0.01 |
| HDL-cholesterol (mg/dL) | 50.6 ± 14.8 | 50.8 ± 15.3 | 51.3 ± 14.8 | 51.1 ± 14.6 | 52.9 ± 15.7 | < 0.01 |
| Triglycerides (mg/dL) | 112.0 [76.0 – 166.0] | 111.5 [77.0 – 161.0] | 107.5 [73.0 – 156.5] | 103.0 [74.0 – 148.0] | 104.0 [76.0 – 147.0] | < 0.01 |
| LDL-cholesterol (mg/dL) | 110.5 ± 31.1 | 114.6 ± 28.7 | 119.4 ± 30.1 | 122.6 ± 30.9 | 131.5 ± 31.8 | < 0.01 |
| Family History of MI | 343 (47.4 %) | 311 (42.8 %) | 346 (46.7 %) | 349 (48.0 %) | 380 (51.1 %) | 0.03 |
| Body mass index (kg/m2) | 28.2 ± 5.5 | 28.4 ± 5.6 | 28.2 ± 5.4 | 28.3 ± 5.4 | 27.9 ± 5.5 | 0.13 |
| CAC score (AU) | 0 [0 – 81] | 116 [0 – 66] | 0 [0 – 86] | 0 [0 – 65] | 0 [0 – 74] | 0.86 |
| CAC score categories | ||||||
| CAC = 0 | 473 (52.7 %) | 477 (52.8 %) | 475 (52.5 %) | 475 (52.5 %) | 477 (52.9 %) | 0.96 |
| CAC 1-99 | 217 (24.2 %) | 245 (27.1 %) | 216 (23.9 %) | 250 (27.6 %) | 219 (24.3 %) | 0.86 |
| CAC ≥ 100 | 208 (23.2 %) | 182 (20.1 %) | 213 (23.6 %) | 180 (19.9 %) | 205 (22.8 %) | 0.81 |
Values presented are number (proportion) and mean ± standard deviation for normally distributed variables or median [25th-75th percentile] for non-normally distributed variables. All continuous variables are described as mean ± standard deviation, except lipoprotein(a), triglycerides, and CAC score. Divide total cholesterol, HDL-C, and LDL-C by 38.67 and triglycerides by 88.57 to convert mg/dL to mmol/L. Abbreviations: CAC = coronary artery calcium, BP = blood pressure, HDL = high-density lipoprotein, LDL = low-density lipoprotein, MI = myocardial infarction.