Table 2.

Risk factors for 28-day all-cause hospitalization or mortality.

	Univariate analysis aOR (95% CI)	p	Multivariate analysis aOR (95% CI)	p
Age	1.007 (0.998–1.016)	0.131	1.002 (0.993–1.014)	0.55
Sex male	1.878 (1.381–2.590)	<0.001	1.701 (1.199–2.412)	0.003
Obesity	0.802 (0.530–1.215)	0.299
Diabetes mellitus	1.585 (1.128–2.227)	0.008	1.462 (1.000–2.137)	0.05
Chronic hypertension	1.192 (0.865–1.642)	0.284
Ischemic heart disease	0.998 (0.536–1.859)	0.996
Chronic pulmonary disease	0.812 (0.346–1.907)	0.632
Cirrhosis	1.993 (1.089–3.646)	0.025	1.598 (0.816–3.130)	0.17
Solid organ malignancy	1.659 (1.082–2.543)	0.02	1.669 (1.052–2.647)	0.03
Hematological malignancy	2.621 (1.583–4.340)	<0.001	2.553 (1.472–4.426)	<0.001
Autoimmune disease	0.564 (0.369–0.861)	0.008	0.848 (0.529–1.357)	0.49
Solid organ transplant	0.812 (0.439–1.503)	0.507
Hematopoietic stem cell transplant	0.831 (0.106–6.531)	0.86
Systemic immunosuppression	1.184 (0.851–1.648)	0.315
SARS-CoV-2 vaccine	0.413 (0.250–0.682)	<0.001	0.463 (0.272–0.788)	0.005
Antiviral treatment		<0.001		<0.001
No treatment	Ref		Ref
Nirmatrelvir/ritonavir	0.073 (0.030–0.179)		0.084 (0.034–0.207)
Remdesivir	0.303 (0.197–0.466)		0.301 (0.194–0.468)

aOR, adjusted odds ratio; CI, confidence interval.