Table 2.
Univariate and multivariate Cox regression analyses for OS.
| Characteristic | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95%CI | P | HR | 95%CI | P | |
|
Child–Pugh classification(B/A) |
0.446 | 0.210 ∼ 0.951 | 0.037 | 0.658 | 0.289 ∼ 1.499 | 0.319 |
| No. of tumors (≥ 3/<3) | 1.191 | 0.671 ∼ 2.114 | 0.550 | |||
|
Tumor diameter (≥ 5 cm/ <5 cm) |
0.873 | 0.489 ∼ 1.561 | 0.648 | |||
| Portal vein tumor thrombus (yes/no) | 2.881 | 1.389 ∼ 5.975 | 0.004 | 1.913 | 0.868 ∼ 4.214 | 0.107 |
|
Extrahepatic metastases (yes/no) |
1.203 | 0.645 ∼ 2.244 | 0.562 | |||
|
AFP (≥ 400ng/mL/ < 400ng/mL) |
1.914 | 1.132 ∼ 3.234 | 0.015 | 1.608 | 0.929 ∼ 2.782 | 0.089 |
| Treatment option (TACE + T/TACE + TC) | 2.056 | 1.194 ∼ 3.540 | 0.009 | 2.013 | 1.162 ∼ 3.489 | 0.013 |
| Interval of recurrence from initial treatment(<1 year/≥1 year) | 0.473 | 0.248 ∼ 0.900 | 0.023 | 0.534 | 0.277 ∼ 1.030 | 0.061 |
| MVI(Positive/Negative) | 1.109 | 0.658 ∼ 1.869 | 0.699 | |||
AFP, a-fetoprotein; MVI, microvascular invasion; No. of tumors, number of tumors.