Table 3.
Pharmacokinetic parameters of 4-methylaminoantipyrine (4-MAA) after intravenous (IV) administration of tramadol (2 mg∙kg−1) in association with metamizole (10 mg∙kg−1 or 25 mg∙kg−1) in ten donkeys.
| 4-MAA | (Metamizol 10 mg∙kg−1 IV) Macêdo et al., 2021 [20] | T2M10
(Tramadol 2 mg∙kg−1 and Metamizol 10 mg∙kg−1 IV) |
(Metamizol 25 mg∙kg−1 IV) Macêdo et al., 2021 [20] | T2M25 (Tramadol 2 mg∙kg−1 and Metamizol 25 mg∙kg−1 IV) |
|---|---|---|---|---|
| C0 (µg/mL) | 31 ± 9.7 a | 109 ± 29 b | 100 ± 34 b | 128 ± 30 b |
| AUC0 → ∞ (h.µg/mL) | 14.51 ± 1.9 a | 53.70 ± 7.3 b | 44.78 ± 5.5 b | 52.2 ± 4.4 b |
| T1/2 (h) | 2.69 ± 0.34 a | 2.05 ± 0.19 a | 3.62 ± 0.24 b | 4.51 ± 0.94 b |
| Vz (L/h/kg) | NA | 1.6 ± 0.1 a | NA | 3.4 ± 0.2 b |
| Cl (L/h/kg) | NA | 5.0 ± 0.5 | NA | 4.9 ± 0.5 |
| MRT0 → ∞ (h) | 2.84 ± 0.3 a | 1.92 ± 0.24 a | 3.92 ± 0.36 b | 3.99 ± 0.74 b |
Notes: Results are presented as the mean ± SD of n = 10. a, b: Different subscript letters show statistical differences between treatments (p < 0.05). C0: extrapolated concentration without time 0; AUC0 → ∞: area under the curve from time zero to infinity; T1/2: elimination half-life; Vz: volume of distribution; Cl: clearance; MRT0 → ∞: mean residence time from zero to infinity; NA: not applicable.