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. 2024 Feb 22;9(4):e176147. doi: 10.1172/jci.insight.176147

Figure 1. Ratings of insensitivity in individuals with WS or 7q11.23 duplication or their siblings.

Figure 1

(A) Average and individual data p oints of parental rating of pain response following tissue-damaging accidents or other pain-producing events. Significantly lower pain sensitivity is reported for individuals with 3 copies of the 7q11.23 locus (P < 0.0001, Kruskal-Wallis; +/+/+ Dup7, n = 10; +/+ Dup7 sibs, n = 5; +/– WS, n = 12; +/+ WS sibs, n = 10). sibs, siblings. (B–D) Example of tissue damage from dog bites that did not produce a pain reaction in this individual with Dup7 despite copious bleeding and the necessity for surgical repair (D).