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. 2024 Feb 8;9(3):e169138. doi: 10.1172/jci.insight.169138

Figure 3. Pharmacological inhibition of RAGE attenuates diet induced NASH.

Figure 3

(A) Schematic depicting experimental design for pharmacological inhibition of RAGE. (B) Representative images of H&E-stained livers from vehicle- or TTP488-treated chow (n = 7 and n = 8, respectively) and FFC mice (n = 11 and n = 10, respectively) demonstrating inflammatory foci (inset showing region of interest at same magnification). Scale bar: 50 μm. (C) Distribution of inflammation and steatosis subscores of the NAFLD activity score. (D) Comparison of serum ALT levels standardized to vehicle-treated chow mice (Chow-vehicle n = 7, Chow-TTP n = 8, FFC vehicle n = 10, FFC-TTP n = 9; P < 0.05). (E) Comparison of body mass (Chow-vehicle n = 7, Chow-TTP n = 8, FFC vehicle n = 10, FFC-TTP n = 9; P < 0.001) and relative liver mass (Chow-vehicle n = 7, Chow-TTP n = 8, FFC vehicle n = 10, FFC-TTP n = 9; P < 0.001). (F) Liver triglyceride content (Chow-vehicle n = 4, Chow-TTP n = 4, FFC vehicle n = 5, FFC-TTP n = 5; P < 0.05). Mann-Whitney U test was used for statistical analyses, and P values were adjusted by the Benjamini-Hochberg method for multiple comparisons.