Figure 4. TTP488 attenuates accumulation of RAGE⁺ recruited macrophages.

(A) Quantification of CD45⁺ cells in livers from vehicle- or TTP488-treated chow and FFC mice (Chow-vehicle n = 3, Chow-TTP n = 4, FFC vehicle n = 5, FFC-TTP n = 7; P < 0.05). (B) Total macrophages (P < 0.05). (C) Resident macrophages (CD11b^intF4/80^hi) (P = 0.06). (D) Recruited (CD11b^hi F4/80^int) macrophages (P < 0.05). (E) Representative flow cytometry gating depicting recruited (CD11b^hiF4/80^int) and resident macrophages (CD11b^intF4/80^hi) macrophages. (F) Quantification of RAGE⁺ recruited macrophages (P < 0.05). (G) Quantification of RAGE⁺ resident macrophages (P < 0.05). Cell numbers are presented as cell count per gram of liver. Mann-Whitney U test was used for statistical analyses, and P values were adjusted by the Benjamini-Hochberg method for multiple comparisons.