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The stability of NZ2114 and NZ2114-NPs under different physiological conditions. (A–C) Peptide retention of NZ2114 and NZ2114-NPs at serum concentrations of 50%, 25% and 12.5%, respectively. (D) Effects of pepsin and trypsin on the antimicrobial activity of NZ2114 and NZ2114-NPs against S. epidermidis G4. NZ2114-NPs: PLGA-encapsulated NZ2114 (formulation-13). Results are given as mean ± SD (n = 3).
