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. 2024 Mar 6;13(3):324. doi: 10.3390/antiox13030324

Figure 5.

Figure 5

Dietary silybin supplementation protected against PQ-induced mitochondrial dysfunction. (A,B) The activities of COX Ⅰ and COX Ⅴ in the liver. (C) The level of ATP. (D) The expression of mitochondrial respiratory chain protein complex genes including NDUFS2, NDUFV2, SDHA, UQCRB, and ATP5H. (E–G) The relative protein expression level of Drp1 and Mfn2. Ctrl, piglets were given a basal diet and were challenged with saline; Si, piglets were given a silybin-supplemented diet and were challenged with saline; PQ, piglets were given a basal diet and were challenged with paraquat; Si + PQ, piglets were given a silybin-supplemented diet and were challenged with paraquat; COX, mitochondrial complex; ATP, adenosine triphosphate. NDUFS2, NADH ubiquinone oxidoreductase core subunit S2; NDUFV2, NADH ubiquinone oxidoreductase core subunit V2; SDHA, succinate dehydrogenase complex flavoprotein subunit A; UQCRB, ubiquinol-cytochrome c reductase binding protein; ATP5H, ATP synthase subunit d; Drp1, dynamin 1; Mfn2, mitofusin 2. Data are expressed as mean ± standard error (n = 6). * p < 0.05, ** p < 0.01.