Table 2.
Accuracy of single or biomarker combinations for differentiating PTB disease at diagnosis (T0) from treated and cured profiles (T2).
| Biomarkers | AUC | SE | SP | CutOff | ACC | NPV | PPV |
|---|---|---|---|---|---|---|---|
| Body Mass Index (BMI) | 0.65 | 60% | 67% | 0.53 | 63% | 60% | 67% |
| Hemoglobin (HB; g/dL) | 0.79 | 53% | 93% | 0.68 | 72% | 63% | 90% |
| WBC absolute count (WBCc;/mm3) | 0.77 | 63% | 86% | 0.54 | 73% | 67% | 83% |
| Lymphocytes (% of WBC) | 0.81 | 81% | 75% | 0.50 | 78% | 78% | 79% |
| [C1q]unstimulated condition | 0.77 | 69% | 79% | 0.60 | 73% | 69% | 79% |
| [C4]unstimulated condition | 0.74 | 59% | 86% | 0.55 | 72% | 65% | 83% |
| [IL-13]rmsHBHA | 0.66 | 78% | 61% | 0.51 | 70% | 71% | 69% |
| [C1q] + [HB] + Lymphocytes + [IL-13]rmsHBHA | 0.93 | 78% | 96% | 0.67 | 87% | 79% | 96% |
| [C1q] + [C4]+ [HB] + [IL-13]rmsHBHA | 0.93 | 88% | 89% | 0.60 | 88% | 86% | 90% |
| [C1q] + [HB] + [IL-13]rmsHBHA | 0.92 | 94% | 79% | 0.41 | 87% | 92% | 83% |
AUC, Area Under the Receiver Operating Characteristic Curve (AUC; ROC); SE, sensitivity; SP, specificity; ACC, accuracy; NPV, negative predictive value; PPV, positive predictive value.