Table 1.
Thermodynamic parameters for the interaction of Aβ(1-42) monomers with unilamellar vesicles. Average values ± SEM (n = 3).
| Monomer | SM/Ch/DMPA (47.5/47.5/5) a | SM/Ch/DMPA (40/40/20) a | SM/Ch/CL (47.5/47.5/5) a | SM/Ch/GM1 (47.5/47.5/5) b | SM/Ch/T. Gang. (47.5/47.5/5) b |
SM/Ch (1/1) |
|---|---|---|---|---|---|---|
| Ka (M−1) (×104) | 3.09 ± 0.9 | 58.2 ± 8.0 | 16.0 ± 2 | 9.4 ± 0.3 | 28.0 ± 2 | - |
| Kd (μM) | 32 ± 1.1 | 1.71 ± 12.5 | 6.25 ± 1.2 | 10.6 ± 0.3 | 3.5 ± 0.2 | - |
| ∆H (kcal/mol) | −7.3 ± 0.05 | −2.8 ± 0.19 | −12.6 ± 1.4 | −15.6 ± 1.4 | −108.2 ± 12 | - |
| ∆S (cal/mol K) | −3.0 ± 0.1 | 8.1 ± 0.2 | −1.68 ± 0.4 | −27.4 ± 1.8 | −324 ± 8 | - |
| ∆G (kcal/mol) | −6.4 ± 0.1 | −5.3 ± 0.01 | −11.96 ± 0.6 | −7.1 ± 0.6 | −7.8 ± 0.6 | - |