Table 3.
Thermodynamic parameters for the interaction of Aβ(1-42) fibrils with unilamellar vesicles. Average values ± SEM (n = 3). Note that values were computed per mol of monomer.
| Fibril | SM/Ch/DMPA (47.5/47.5/5) |
SM/Ch/DMPA (40/40/20) |
SM/Ch/CL (47.5/47.5/5) |
SM/Ch/GM1 (47.5/47.5/5) a |
SM/Ch/T. Gang. (47.5/47.5/5) a |
SM/Ch (1/1) a |
|---|---|---|---|---|---|---|
| Ka (M−1)(×104) | 18.5 ± 2.4 | 27.6 ± 8.2 | 28.6 ± 0.8 | 18.0 ± 0.7 | 13.0 ± 0.3 | 21.0 ± 0.4 |
| Kd (µM) | 5.4 ± 0.18 | 3.6 ± 0.12 | 3.5 ± 0.3 | 5.6 ± 0.2 | 7.6 ± 0.3 | 4.8 ± 0.7 |
| ∆H (kcal/mol) |
−6.14 ± 0.3 | −8.41 ± 0.405 | −4.31 ± 0.07 | −1.78 ± 0.05 | −29.6 ± 0.4 | −0.87 ± 0.05 |
| ∆S (cal/mol K) |
4.31 ± 0.08 | −2.22 ± 0.05 | 11.1 ± 0.2 | 18.3 ± 0.7 | −71.9 ± 1.8 | 21.6 ± 0.2 |
| ∆G (kcal/mol) |
−7.47 ± 0.02 | −7.72 ± 0.03 | −7.75 ± 0.06 | −7.45 ± 0.08 | −7.27 ± 0.05 | −7.56 ± 0.04 |
a Ahyayauch et al. [18].