Table 4.
Changes in surface pressure of lipid monolayers upon insertion of Aβ(1-42) peptide: a summary of results. Data derived from experiments as in Figure 2, Figure 3 and Figure 4. Average values ± SEM (n = 3).
| Lipid Composition | ∆π (mN/m) at πi = 16 mN/m |
Maximal Insertionpressures | |
|---|---|---|---|
| SM/Ch a | Monomers | 4.5 ± 0.3 | 32 ± 0.5 |
| Oligomers | 6.0 ± 0.2 | 26 ± 0.0 | |
| Fibrils | 1.94 ± 0.2 | 21 ± 0.4 | |
| SM/Ch/DMPA (5%) | Monomers | 11.0 ± 0.6 | 32 ± 0.0 |
| Oligomers | 6.5 ± 0.7 | 28 ± 0.2 | |
| Fibrils | 5.0 ± 0.4 | 26 ± 0.3 | |
| SM/Ch/DMPA (20%) | Monomers | 9.2 ± 0.5 | 30 ± 0.1 |
| Oligomers | 5.5 ± 0.1 | 27 ± 0.2 | |
| Fibrils | 5.3 ± 0.2 | 26 ± 0.4 | |
| SM/Ch/CL (5%) | Monomers | 12.0 ± 1 | 32 ± 0.0 |
| Oligomers | 6.4 ± 0.2 | 27 ± 0.1 | |
| Fibrils | 4.2 ± 0.1 | 26 ± 0.2 | |
| SM/Ch/GM1 (5%) a | Monomers | 17.1 ± 0.4 | 34 ± 0.2 |
| Oligomers | 12.4 ± 0.5 | 32 ± 0.0 | |
| Fibrils | 3.5 ± 0.5 | 24 ± 0.5 | |
| SM/Ch/total ganglioside (5%) a | Monomers | 11.7 ± 0.5 | 34 ± 0.0 |
| Oligomers | 8.5 ± 0.6 | 31 ± 0.3 | |
| Fibrils | 2.7 ± 0.2 | 24 ± 0.4 | |
a Ahyayauch et al. [18].