Table 4.
Nrf2 target genes and biochemical functions.
| Enzyme Name | Protein Symbol | Biochemical Function |
|---|---|---|
| Alcohol dehydrogenase | ADH | Antioxidant and detoxification enzymes [137,138] |
| Aldehyde dehydrogenase | ALDH | |
| Aldo-keto reductase family 1 | AKR1 | |
| ATP-binding cassette subfamily B/C | ABCB/ABCC | |
| Carbonyl reductase | CBR | |
| Catalase | CAT | |
| Cytochrome P450 | CYP1B1 | |
| Epoxide hydrolase, microsomal | EXPH | |
| Glutamate-cysteine ligase | GCL | |
| Glutathione peroxidase | GPx | |
| Glutathione reductase | GR | |
| Glutathione S-transferase | GST | |
| Glutathione synthase | GSS | |
| Heme oxygenase-1 | HO-1 | |
| NADPH-quinone oxidoreductase-1 | NQO-1 | |
| Peroxiredoxins | PRDX1 | |
| Prostaglandin reductase | PTGR | |
| Sodium independent cysteine glutamate antiporter | SLC7A11 | |
| Sulfiredoxin1 | SRXN1 | |
| Superoxide dismutase | SOD | |
| Thioredoxin | TXN | |
| Thioredoxin reductase | TXNRD | |
| UDP-glucuronosyl transferase | UGT | |
| Ferritin light/heavy chain | FTL /FTH | Iron metabolism [139] |
| Glucose-6-phosphate dehydrogenase | G6PD | Bioenergetic function [140] |
| 6-phophogluconate dehydrogenase | PGD | |
| Malic enzyme | ME | |
| NADP-dependent isocitrate dehydrogenase | IDH | |
| B-cell lymphoma | BCL | Apoptosis [141] |
| Autophagy protein | ATG | Autophagy [141] |
| Microtubule-associated protein1A/1B-light chain 3B | LC3B | |
| Activating transcription factor | ATF | Proteasomal degradation [142] |
| Proteasomes | PSM | |
| Sequestosome (p62) | SQSTM |