Figure 6.

DHZ and DHZ-DIM prevent the loss of dopaminergic neurons. Both compounds at 1 mM significantly prevented the loss of dopaminergic neurons in all posterior clusters at 14 days of treatment, whereas at 21 days, a significant prevention of dopaminergic neuron loss was observed only with the DHZ-DIM treatment. * p < 0.05, ** p < 0.01, *** p < 0.001 and **** p < 0.0001 indicate significant differences between LRRK2 vehicle and LRRK2 treated with DHZ, DHZ-DIM or vehicle and treated WT groups. ^§ p < 0.0001 LRRK treated with DHZ-DIM vs. LRRK treated with DHZ.