Fig. 2.

Weight change, blood glucose, and ketone levels in brain tumor bearing NOD/SCID mice under STD, ATD+KE, and KD dietary interventions. (A) Body weight was presented as a percent of weight at the start of dietary intervention. Compared to STD, no statistically significant changes occurred in animals’ body weight. (B) Both the KD and ATD+KE had significantly lower glucose compared to the STD group, and also glucose level in the KD group was significantly lower than the ATD+KE. (C) β-hydroxybutyrate (β-HB) was significantly higher in the KD as compared to the STD and ATD+KE groups. Moreover, β-HB level in ATD+KE was also significantly elevated relative to the STD alone group (**P<0.0021, ****P<0.0001; one-way ANOVA). KD, ketogenic diet; STD, standard diet; ATD, Atkins-type diet; KE, ketone ester.