Figure 4.

Quantification of telomere length in circulating lymphocytes of DSDs patients. (A) Distribution of the telomere lengths in circulating lymphocytes of patients YH013 and YH030 that exhibit the most extreme telomere lengths in our DSDs cohort. The mean telomere length is presented by the red line and the frequency of cells with extreme telomere shortening (<5 kb) is presented as a dashed blue line. The different quartiles of fluorescence signal intensities in telomeres are also shown. (B) Telomere length (kb) as a function of age in lymphocytes from healthy donors (150 donors, mean age 36 years, range 0.5–79 years) (red circles) and in DSDs patients (blue triangle). (C) A significant difference between the means of telomere length of DSD patients and those from healthy donors with similar ages.