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. 2024 Mar 25;16(1):2329147. doi: 10.1080/19490976.2024.2329147

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© 2024 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 4. — R-equol alleviates DSS-induced colitis through increasing the Foxp3+T cells.

(a) the volcano plot of differential metabolites and the level of R-equol in fecal contents between DSS+ATCC25526 and vehicle group. (b) Experimental design. (c) Percentage change of body weight during the whole experimental time. (d) Disease activity index evaluated at sacrifice. (e) Representative images and length of the colon. (f) the image of H&E staining of the colon and pathological score. (g) the proportion of CD45+ CD4+ IL17A+ Th17 cells and CD45+CD4+Foxp3+ Treg cells in colon tissue. (h) the level of IL10 and IL17 in serum.

Data are expressed as mean±SE, n = 4-11, **p＜0.01，***p＜0.001