Table 2.

Comparisons of O₂⁻ and SOD values between the groups. A p-value of less than 0.05 was considered statistically significant (*—p < 0.05; **—p < 0.01).

Superoxide Anion Radical (O2−)
	Before the initiation	52nd week
Control vs. MTX	p < 0.01 **	p > 0.05
Control vs. secukinumab	p < 0.01 **	p > 0.05
Control vs. ustekinumab	p < 0.01 **	p > 0.05
MTX vs. secukinumab	p > 0.05	p > 0.05
MTX vs. ustekinumab	p > 0.05	p > 0.05
Secukinumab vs. ustekinumab	p > 0.05	p > 0.05
Superoxide Dismutase (SOD)
Control vs. MTX	p < 0.01 **	p < 0.01 **
Control vs. secukinumab	p < 0.01 **	p < 0.01 **
Control vs. ustekinumab	p < 0.01 **	p < 0.01 **
MTX vs. secukinumab	p > 0.05	p < 0.05 *
MTX vs. ustekinumab	p > 0.05	p < 0.01 **
Secukinumab vs. ustekinumab	p > 0.05	p < 0.01 **

Abbreviations: MTX—methotrexate.