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. 2024 Mar 8;13(3):173. doi: 10.3390/biology13030173

Figure 3.

Figure 3

Position of novel genetic variants in the exons 3 and 4 (red boxes) of the RUNX2 gene and the position of amino acid changes in the domain RHD (blue rectangle) of the RUNX2 protein. The lower image shows the secondary structure of the protein with its domains QA: glutamine/alanine domain (purple), RHD: Runt homologous domain (blue), NLS: nuclear localization signal region (green), and NMTS: nuclear matrix-targeting sequence domain (yellow). 1: the first activation domain (purple triangle), CRM: the conserved repressive motif (orange rectangle).