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Our ‘iceberg model’ of the new treatment philosophy for mUC. Abbreviations: ctDNA: circulating tumor DNA; DDR: DNA damage response and repair; EV: enfortumab vedotin; FGFR: fibroblast growth factor receptor; HER2: human epidermal growth factor 2; ICIs: immune checkpoint inhibitors; MSS: microsatellite status; MTAP: methylthioadenosine phosphorylase; P: pembrolizumab; TMB: tumor mutational burden.
