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RF inhibited the growth of various cancer cell lines. (A) The molecular structure of RF. (B) Cell viability of A549, MCF-7, HepG2, H292, U937, and SW480 treated with RF at the indicated concentrations and time. (C) IC50 values of RF in various cell lines. All data are presented as the mean ± SD from a minimum of three independent experiments. Statistical differences were assessed using one-way ANOVA. * p < 0.05, ** p < 0.01, and *** p < 0.001 compared to the control. RF, rotundifuran.
