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. 2024 Mar 3;12(3):570. doi: 10.3390/biomedicines12030570
1,4-TzlNBA nucleobase amino acid bearing of nucleobase attached to the side chain via 1,4-linked 1,2,3-triazole moiety
Ac acetyl
ACN acetonitrile
ARR arginine-rich region
B, BH nucleobase
C18 octadodecane chain
CuAAC Cu(I)-catalyzed azide-alkyne cycloaddition
DCM dichloromethane
DMAP 4-Dimethylaminopyridine
DMF N,N-dimethylformamide
FAM fluorescein
Fmoc fluorenylmethyloxycarbonyl
Fmoc-Aha Fmoc-L-azidohomoalanine
Hal L-homoalanine
HalTzl nucleopeptide designed on the basis of L-azidohomoalanine (Hal), containing nucleobases attached through a 1,4-linked-triazole linker to the Hal’s side chain
HATU [dimethylamino(triazolo[4,5-b]pyridin-3-yloxy)methylidene]-dimethylazanium;3-hydroxytriazolo[4,5-b]pyridine hexafluorophosphate
HIV-1 human immunodeficiency virus type 1
HOAt 1-Hydroxy-7-azabenzotriazole
MeOH methanol
NBA nucleobase amino acid
NP nucleopeptide
PNA peptide nucleic acid
RNAP II RNA polymerase II
RT reverse transcriptase
SPPS solid-phase peptide synthesis
TAR trans-activation response element
TB tris/borate buffer
t-BuOH tert-butanol
TFA trifluoroacetic acid
Tzl 1,2,3-triazol