Table 2. MRS analysis and tissue segmentation in the measured voxels.
| mild WMH (n = 46) | moderate to severe WMH (n = 41) | p-value | |
| ACC | |||
| GABA+/Cra | 0.10 (0.09–0.11) | 0.10(0.09–0.11) | 0.034* |
| Glx/Cra | 0.07 (0.07–0.08) | 0.07 (0.06–0.08) | 0.676 |
| GABA+ fitting errors (%) | 8.00 (6.71–9.78) | 8.17 (6.15–9.91) | 0.683 |
| Glx fitting errors (%) | 7.62 (6.27–8.89) | 7.11 (6.23–10.89) | 0.766 |
| FWHM (Hz) | 9.16 (8.67–9.49) | 9.16 (8.54–9.58) | 0.990 |
| GM/(GM + WM) (%) | 54.02 ± 4.45 | 54.54 ± 5.54 | 0.637 |
| PCC | |||
| GABA+/Cra | 0.12 (0.11–0.13) | 0.12 (0.11–0.13) | 0.302 |
| Glx/Cra | 0.06 (0.06–0.07) | 0.07 (0.06–0.07) | 0.668 |
| GABA+ fitting errors (%) | 6.66 (5.65–7.60) | 7.00 (5.97–7.78) | 0.575 |
| Glx fitting errors (%) | 7.08 (6.08–9.18) | 7.13 (6.00–7.99) | 0.560 |
| FWHM (Hz) | 8.97 (8.57–9.25) | 8.91 (8.79–9.16) | 0.710 |
| GM/(GM + WM) (%) | 59.28 ± 3.36 | 58.15 ± 4.91 | 0.218 |
Data are mean ± SD, or median (IQR, interquartile range). Abbreviations: WMH: white matter hyperintensities; GABA+: GABA plus co-edited macromolecules and homocarnosine; Glx: glutamate-glutamine; FWHM: full-width at half-maximum; GM: gray matter; WM: white matter. aAfter correction for age, gender, and education level. Data are median (IQR, interquartile range). *p < 0.05, **p < 0.01, ***p < 0.001.