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. 2024 Mar 12;16(6):1131. doi: 10.3390/cancers16061131

Figure 1.

Figure 1

Schematics for DDX3X and DDX3Y. (a) Human isoform 1 DDX3X and DDX3Y proteins share ~92% identity in their amino acid sequences. The amino acids that are different between DDX3X and DDX3Y are indicated in red. (b) DDX3X contains two RecA-like domains that construct the conservative Asp-Glu-Ala-Asp (DEAD)-box helicase core. Within the domains, there are twelve signature motifs that are responsible for ATP binding and hydrolysis (motifs Q, I, II, and VI), RNA binding (motifs Ia, Ib, Ic, IV, IVa, and V), and RNA/ATP recognition (motifs III and Va). Two nuclear export signals (NESs) have been identified at both the N- and C- terminus, with an eIF4E-binding site located at the N-terminus. NTE, N-terminal extension; CTE, C-terminal extension.