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Mechanisms of DDX3X-mediated regulation of stress granules in drug resistance. (a) Under stress, stress granules (SGs) can sequester pro-apoptotic factors and prevent apoptosis. (b) DDX3X can bind to target mRNA and capture it in SGs, resulting in translational repression. Then, the absence of therapeutic targets leads to drug resistance. (c) In medulloblastoma, DDX3X mutations lead to increased SGs assembly, enhancing the mechanisms described in (a,b).
