PD-1	Programmed cell death protein-1
PD-L1	Programmed death ligand-1
CTLA-4	Cytotoxic T lymphocyte-associated antigen-4
TME	Tumor microenvironment
ITIM	Immunoreceptor tyrosine-based inhibitory motif
ITSM	Intracellular domain of immunoreceptor tyrosine-based switch motif
MHC	Major histocompatibility complex
APCs	Antigen-presenting cells
IL-2	Interleukin-2
IFN-γ	Interferon-γ
N-SH2	N-terminal
C-SH2	C-terminal
SH2	Src homology-2
DHHC	Asp-His-His-Cys
E1	Ubiquitin-activating enzyme
E2	Ubiquitin-conjugating enzyme
E3	Ubiquitin-protein ligase
ER	Endoplasmic reticulum
SHP	Src homology-2 domain-containing protein tyrosine phosphatase
PTM	Post-translational modification