TABLE 2.
Antibody responses in chronic and convalescent chimpanzees
| Group | Chimp no. | Mo PIa | HCV RNAb | RIBA analysisc
|
||||
|---|---|---|---|---|---|---|---|---|
| Capsid | NS3-1 | NS3-2 | NS4 | NS5 | ||||
| With persistent HCV infection | x174 | 0 | − | − | − | − | − | − |
| 2.6 | + | − | 1+ | − | 2+ | − | ||
| 3.1 | + | − | 2+ | 2+ | 2+ | − | ||
| 75 | + | 2+ | 4+ | 2+ | 2+ | 3+ | ||
| 85 | + | 2+ | 4+ | 2+ | 2+ | 3+ | ||
| x196 | −2.7 | − | − | − | − | − | − | |
| 62 | + | − | − | − | − | 1+ | ||
| 68 | + | − | 4+ | 1+ | 2+ | 3+ | ||
| 77 | + | − | 4+ | 1+ | 2+ | 3+ | ||
| With viral clearance | x194 | −0.2 | − | − | − | − | 1+ | − |
| 2 | + | − | 1+ | − | 2+ | − | ||
| 4.8 | − | − | 2+ | − | 2+ | − | ||
| 66d | − | − | 2+ | − | 2+ | − | ||
| x198 | −0.2 | − | − | − | − | − | − | |
| 2.9 | + | − | 3+ | − | 2+ | 2+ | ||
| 64d | − | − | 2+ | − | 1+ | − | ||
| x268 | −0.2 | − | − | − | − | − | − | |
| 2.6 | + | 1+ | − | − | − | − | ||
| 3.3 | − | 1+ | 2+ | − | 1+ | − | ||
| 7.3d | − | − | 2+ | − | − | − | ||
| 61d | − | − | 1+ | − | − | − | ||
| x007 | −2.8 | − | − | − | − | − | − | |
| 1.8 | + | − | − | − | 2+ | − | ||
| 2.2 | − | − | 1+ | − | 2+ | − | ||
| 6.9d | − | − | 1+ | − | − | − | ||
| 67d | − | − | − | − | − | − | ||
a
Negative values indicate prebleeds taken before inoculation.
b
Detected by RT-PCR as described in Materials and Methods.
c
Serum samples were analyzed by RIBA; the intensity of the reaction is designated negative (−) to 4+ as indicated by the manufacturer.
d
Sample taken at a time when the animal was no longer ELISA positive.