Table 5.
Univariate regression analysis of associated factors which influenced the duration from initiating NCPAP weaning to achieving complete room air and total number of days of respiratory therapy.
| Item | Duration from Initiating NCPAP Weaning to Achieving Complete Room Air (Days) | Total Number of Days of Respiratory Therapy | ||||||
|---|---|---|---|---|---|---|---|---|
| Regression Coefficient | Lower 95% CI | Upper 95% CI | p Value | Regression Coefficient | Lower 95% CI | Upper 95% CI | p Value | |
| Room air-HFNC @ | −10.468 | −16.077 | −4.858 | <0.001 * | −24.194 | −34.948 | −13.440 | <0.001 * |
| GA | 0.003 | −1.309 | 1.315 | 0.996 | −9.884 | −11.801 | −7.966 | <0.001 * |
| BBW | 0.005 | −0.005 | 0.014 | 0.356 | −0.067 | −0.082 | −0.052 | <0.001 * |
| Female-Male ! | −2.273 | −7.869 | 3.324 | 0.423 | −1.205 | −12.187 | 9.777 | 0.829 |
| C/S-VD # | −4.952 | −10.580 | 0.675 | 0.084 | 1.023 | −10.119 | 12.166 | 0.856 |
| NTISS | 0.048 | −0.333 | 0.429 | 0.805 | 0.712 | −0.025 | 1.448 | 0.058 |
| 1′ Apgar score | −1.410 | −2.907 | 0.087 | 0.065 | −5.738 | −8.537 | −2.939 | <0.001 * |
| 5′ Apgar score | −0.806 | −2.210 | 0.598 | 0.258 | −4.594 | −7.239 | −1.948 | <0.001 * |
| RDS grade | 3.677 | −0.284 | 7.639 | 0.069 | 9.489 | 1.807 | 17.171 | 0.016 * |
| Surfactant usage | 1.259 | −4.414 | 6.933 | 0.661 | 12.461 | 1.556 | 23.366 | 0.025 * |
| Intubation after birth | 7.329 | 1.507 | 13.151 | 0.014 * | 11.921 | 0.440 | 23.402 | 0.042 * |
| Apnea medicine | ||||||||
| Used–not used $ | −3.793 | −12.385 | 4.799 | 0.384 | 1.492 | −15.377 | 18.360 | 0.861 |
| Caffeine- Theophylline ^ |
−2.264 | −8.559 | 4.029 | 0.478 | 14.977 | 1.774 | 28.180 | 0.027 * |
| pRBC transfusion | 1.758 | −4.440 | 7.956 | 0.576 | 6.226 | −5.875 | 18.327 | 0.311 |
| PDA | ||||||||
| Without Tx | −4.144 | −11.076 | 2.789 | 0.239 | −8.179 | −21.749 | 5.392 | 0.235 |
| Conservative Tx | −3.557 | −9.217 | 2.102 | 0.216 | 3.968 | −7.155 | 15.091 | 0.482 |
| BPD ≥ moderate | 0.188 | −5.578 | 5.954 | 0.949 | −0.604 | −11.891 | 10.683 | 0.916 |
| IVH ≥ grade III | −6.193 | −19.658 | 7.272 | 0.365 | 3.316 | −23.120 | 29.753 | 0.804 |
| Late-onset sepsis | ||||||||
| B/C proved | 4.019 | −4.146 | 12.185 | 0.332 | 2.634 | −13.403 | 18.671 | 0.746 |
| Clinical diagnosis | −2.392 | −9.794 | 5.009 | 0.524 | 3.259 | −11.242 | 17.760 | 0.657 |
| Hypotension | 3.863 | −3.796 | 11.522 | 0.320 | 3.449 | −11.589 | 18.488 | 0.651 |
| ROP ≥ stage III | −3.335 | −10.380 | 3.711 | 0.351 | 26.772 | 13.729 | 39.814 | <0.001 * |
| NEC ≥ stage II | 18.363 | −4.453 | 41.178 | 0.114 | −28.935 | −73.752 | 15.882 | 0.204 |
* p value < 0.05; @ Compared room air group to HFNC group; ! compared female to male; # compared C/S to VD; $ compared used to not used; ^ compared Caffeine to Theophylline; NCPAP, nasal continuous positive airway pressure; HFNC, high-flow nasal cannula; CI, confidence interval; GA, gestational age; BBW, birth body weight; VD, vaginal delivery; C/S, cesarean section; Tx, treatment; NTISS, Neonatal Therapeutic Intervention Scoring System; B/C, blood culture; RDS, respiratory distress syndrome; pRBC, packed red blood cell; BPD, bronchopulmonary dysplasia; PDA, patent ductus arteriosus; IVH, intraventricular hemorrhage; ROP, retinopathy of prematurity; NEC, necrotizing enterocolitis.