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. 2024 Mar 21;46(3):2713–2740. doi: 10.3390/cimb46030171

Table 4.

List of the 25 genes with the most statistically significant changes during the whole period of trastuzumab resistance development in both cell lines: BT474 and SKBR3.

Top 25 Most Significant in BT474 Cell Line
Gene Adj p-Val Gene Adj p-Val
KLK11 7.6 × 10103 ZNF195 2.0 × 10−51
IGF2BP1 3.4 × 10−72 C6orf48 2.2 × 10−51
GSTM3 1.6 × 10−65 ADM 2.7 × 10−51
IGFBP3 3.5 × 10−64 RND3 2.7 × 10−51
TNFRSF11B 1.1 × 10−63 CBPB 1.9 × 10−50
RASD1 3.8 × 10−61 PLA2G16 1.5 × 10−49
CHAF1B 3.8 × 10−58 2F1 1.5 × 10−49
TRIT1 1.7 × 10−56 KIAA0586 3.4 × 10−49
PMP22 8.1 × 10−55 ADK 3.7 × 10−49
PSN1 1.4 × 10−53 TFRC 4.0 × 10−49
PLAT 2.5 × 10−53 CNP 8.2 × 10−48
BIRC5 2.7 × 10−52 RO1L 3.1 × 10−47
USP1 2.0 × 10−51
Top 25 Most Significant in SKBR3 Cell Line
Gene Adj p-Val Gene Adj p-Val
CCL2 7.7 × 10108 HN1 6.6 × 10−90
F8A1 2.7 × 10104 C20orf24 8.3 × 10−90
E2F1 1.0 × 10102 EXO1 1.1 × 10−88
GINS2 6.4 × 10100 KIAA0101 4.3 × 10−88
YWHAH 6.4 × 10100 TFRC 2.6 × 10−87
PRMT6 7.7 × 10100 NACC2 1.5 × 10−86
DTL 7.8 × 10−99 DDIT4 2.5 × 10−86
GSTP1 4.4 × 10−98 CNOT10 2.8 × 10−86
BIRC5 6.5 × 10−98 FAHD1 7.3 × 10−84
DOLK 6.5 × 10−98 USP1 7.3 × 10−84
SAP30 7.5 × 10−92 MGST2 1.7 × 10−83
RPP40 1.3 × 10−91 BRCA1 2.5 × 10−83
RTN4IP1 3.9 × 10−90