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. 2024 Mar 21;46(3):2713–2740. doi: 10.3390/cimb46030171

Table 10.

Top 10 most significant and enriched resp. Molecular Function Gene Ontology (GO) terms out of a total of 103 that have been identified for the BT474 cell line. A complete list of significant and top 20 enriched GO terms in Table S9.

MF GO Term Analysis for BT474 Cell Line
Top 10 Most Significant MF Top 10 Most Enriched MF
GO Terms GO Terms
ID Term Adjusted p-Value ID Term % Signif/All
GO:0005515 protin binding 1.3 × 10−12 GO:0003688 DNA rplication origin binding 86.00
GO:0003697 single-stranded DNA binding 2.1 × 10−5 GO:0030983 mismatched DNA binding 86.00
GO:0003677 DNA binding 3.9 × 10−5 GO:0097617 annealing activity 85.00
GO:0003688 DNA replication origin binding 5.3 × 10−5 GO:1990825 sequence-specific mRNA binding 80.00
GO:0030983 mismatched DNA binding 5.3 × 10−5 GO:0008242 omega peptidase activity 77.00
GO:0003682 chromatin binding 7.6 × 10−5 GO:0043138 3′-5′ DNA helicase activity 75.00
GO:0003723 RNA binding 1.3 × 10−4 GO:0031996 thioesterase binding 73.00
GO:0097617 annealing activity 1.4 × 10−4 GO:0004303 estradiol 17-beta dehydrogenase activity activity 73.00
GO:0030331 estrogen receptor binding 9.0 × 10−4 GO:0000400 four-way junction DNA binding 69.00
GO:0048027 mRNA 5′-UTR binding 1.1 × 10−3 GO:0031994 insulin-like growth factor I binding 69.00