FIG. 3.

(A) Viral antigens, inflammation, and tissue destruction in the brain (hippocampus) of a perforin-deficient mouse on day 8 p.i. Arrows point to examples of neurons containing viral antigens. Final magnification, ×427. (B) Viral antigens in a large motoneuron of the spinal cord (arrow) and intense inflammation in a perforin-deficient mouse on day 8 p.i. Final magnification, ×427. (C) Large amount of viral antigens, tissue destruction, and inflammation in the hippocampus of a perforin-deficient mouse on day 11 p.i. Final magnification, ×267. (D) Infected cell (arrow) and inflammation in the white matter of a perforin-deficient mouse on day 18 p.i. Final magnification, ×427.