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. 2024 Mar 8;13(6):480. doi: 10.3390/cells13060480

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© 2024 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Co-localization of cannabinoid type 1 (CB1) receptor with Neu-1. CB1 receptors co-localized with Neu-1 in naïve, unstimulated RAW-Blue (A), PANC-1 (B), and SW-620 (C) cells. For analysis of co-localization, cells were fixed, permeabilized, blocked, and immunostained with anti-CB1 conjugated with AlexaFluor 594 (red) and anti-Neu-1 conjugated with AlexaFluor 488 (green). Co-localization was quantified using AxioVision imaging software to compute the Pearson correlation coefficient, measuring the linear association between two variables (40× objective). The Pearson correlation coefficient for co-localization between CB1 receptors and Neu-1 was 0.5917 in RAW-Blue (A), 0.6467 in PANC-1 (B), and 0.6455 in SW-620 (C), affirming CB1-Neu1 receptor proximity.

Co-localization of cannabinoid type 1 (CB1) receptor with Neu-1. CB1 receptors co-localized with Neu-1 in naïve, unstimulated RAW-Blue (A), PANC-1 (B), and SW-620 (C) cells. For analysis of co-localization, cells were fixed, permeabilized, blocked, and immunostained with anti-CB1 conjugated with AlexaFluor 594 (red) and anti-Neu-1 conjugated with AlexaFluor 488 (green). Co-localization was quantified using AxioVision imaging software to compute the Pearson correlation coefficient, measuring the linear association between two variables (40× objective). The Pearson correlation coefficient for co-localization between CB1 receptors and Neu-1 was 0.5917 in RAW-Blue (A), 0.6467 in PANC-1 (B), and 0.6455 in SW-620 (C), affirming CB1-Neu1 receptor proximity.