Table 2.

(a) Risk factors for clinical instability after 48 h of therapy or in-hospital death—univariate analysis; (b) independent risk factors for clinical instability after 48 h of therapy or in-hospital death.

(a)
	Clinically Stable at 48 h and No Death n = 65		Clinically Unstable at 48 h or Death n = 36
	Mean	[SD]	Mean	[SD]	p-Value
Age	79.9	[11.3]	76.3	[13.2]	0.249
Days of hospitalization	12.8	[10.1]	12.1	[10.9]	0.524
Delay until reassessment of empirical therapy (days)	3.6	[1.9]	3.3	[2.7]	0.201
Days of antibiotic therapy	14.0	[7.1]	10.4	[9.5]	0.010
qPitt score	0.5	[0.77]	0.8	[0.95]	0.123
White-cell count (cc/mmcc)	13,622.2	[8757.7]	14,068.3	[7650.2]	0.618
C-reactive protein (mg/L)	122.6	[96.8]	153.6	[123.0]	0.242
Procalcitonin (ng/mL)	31.6	[52.3]	38.5	[59.8]	0.777
	n	(%)	n	(%)	p-Value
Gender					0.244
Female	23	(35.4)	17	(47.2)
Male	39	(34.2)	26	(59.1)
Comorbidities					1.000
No	2	(3.1)	1	(2.8)
Yes	63	(96.9)	35	(97.2)
Healthcare associated BSI					0.240
No	51	(79.7)	32	(88.9)
Yes	13	(20.3)	4	(11.1)
ICU at BSI diagnosis					0.663
No	62	(95.4)	33	(91.7)
Yes	3	(4.6)	3	(8.3)
qPitt score					0.257
<2	56	(86.2)	27	(75.0)
≥2	9	(13.8)	9	(25.0)
Septic shock					0.011
No	61	(92.3)	27	(75.0)
Yes	4	(6.2)	9	(25.0)
ESBL					1.000
No	60	(92.3)	30	(90.9)
Yes	5	(7.7)	3	(9.1)
Type of Enterobacterales					0.013
ESCPM group	7	(10.8)	11	(30.6)
Other	58	(89.2)	25	(71.4)
Effective empirical therapy					0.001
No	7	(10.8)	14	(40.0)
Yes	58	(89.2)	21	(60.0)
Type of empirical therapy					0.015
Single therapy	46	(70.8)	14	(45.2)
Combination therapy	19	(29.2)	17	(54.8)
(b)
	AdjOR		[95% CI]		p-Value
Septic shock
No	1
Yes	5.30		[1.47; 22.19]		0.014
Initial empirical antibiotic therapy
Ineffective	5.54		[1.95; 17.01]		0.002
Effective	1