Table 3.
A catalogue of abnormal miRNA diagnostic biomarkers.
| Diagnostic Markers | Specimens | Epigenetic Changes | Sensibility (%) | Specificity (%) | Reference |
|---|---|---|---|---|---|
| miR-92a-1 | serum | up-regulated miRNAs | 81.8 | 95.6 | [143] |
| miR-29a + miR-92a | plasma | up-regulated miRNAs | 83 | 84.7 | [144] |
| miR-92 | plasma | up-regulated miRNAs | 89 | 70 | [145] |
| miR-28-3p + miR-106a-5p + miR-542-5p + let-7e-5p | plasma | up-regulated miRNAs | 99.7 | 90.9 | [146] |
| miR-135b-5p | serum | up-regulated miRNAs | 93.1 | 72.7 | [147] |
| miR-21 | serum | up-regulated miRNAs | 86.05 | 72.97 | [127] |
| miR-21 | serum | up-regulated miRNAs | 82.8 | 90.6 | [148] |
| miR-21 | saliva | up-regulated miRNAs | 97 | 91 | [149] |
| miR-1246+ miR-1268b + miR-4648 | serum | up-regulated miRNAs | 50.7 | 90.2 | [150] |
| miR-106a | tissue | up-regulated miRNAs | 53 | 85 | [151] |
| miR-106b | serum | up-regulated miRNAs | 85.2 | 78 | [152] |
| miR-429 | tissue | up-regulated miRNAs | 71.79 | 62.82 | [153] |
| miR-200c + miR-18a | plasma | up-regulated miRNAs | 84.6 | 75.6 | [154] |
| miR-223 + miR-92a | plasma | up-regulated miRNAs | 76.3 | 68.8 | [155] |
| miR-424-5p | serum | up-regulated miRNAs | 79 | 72.6 | [156] |
| miR-375 | plasma | down-regulated miRNAs | 76.92 | 64.63 | [157] |
| miR-145 | tissue | down-regulated miRNAs | 90 | 88 | [158] |
| miR-23b | tissue | down-regulated miRNAs | 78 | 70 | [158] |
| miR-195 | tissue | down-regulated miRNAs | 72 | 68 | [158] |
| miR-24 | plasma | down-regulated miRNAs | 78.38 | 83.85 | [159] |
| miR-320a | plasma | down-regulated miRNAs | 92.79 | 73.08 | [159] |
| miR-423-5p | plasma | down-regulated miRNAs | 91.89 | 70.77 | [159] |
| mi-24 + mi-320a + mi-423-5p | plasma | down-regulated miRNAs | 92.79 | 70.77 | [159] |
| miR-143-3p | serum | down-regulated miRNAs | 61.3 | 74.2 | [156] |
| miR-135b-5p | stool | up-regulated miRNAs | 96.5 | 74.1 | [147] |
| miR-21 | stool | up-regulated miRNAs | 86.05 | 81.08 | [127] |
| miR-92a | stool | up-regulated miRNAs | 89.7 | 51.7 | [12] |
| miR-144 | stool | up-regulated miRNAs | 78.6 | 66.7 | [12] |
| miR-92a + miR-144 | stool | up-regulated miRNAs | 96.6 | 37.9 | [12] |
| miR-223 + miR-92a | stool | up-regulated miRNAs | 73.9 | 82.2 | [155] |
| miR-20a | stool | up-regulated miRNAs | 55 | 82 | [160] |
| miR-221 | stool | up-regulated miRNAs | 62 | 74 | [161] |
| miR-18a | stool | up-regulated miRNAs | 61 | 69 | [161] |
| miR-221 + miR-18a | stool | up-regulated miRNAs | 66 | 75 | [161] |
| miR-29a | stool | down-regulated miRNAs | 85 | 61 | [162] |
| miR-224 | stool | down-regulated miRNAs | 75 | 63 | [162] |