Table 4.
A catalogue of abnormal miRNA prognostic biomarkers.
| Prognostic Markers | Specimen | Epigenetic Changes | CRC Staging | Reference |
|---|---|---|---|---|
| miR-21 | tissues | up-regulated | adenomas/carcinomas | [163] |
| miR-92a | tissues | up-regulated | adenomas/carcinomas | [164] |
| miR-25 | tissues | up-regulated | advanced (III-IV)/lymph node metastasis/distant metastasis | [165] |
| miR-1246, miR-1268b, miR-4648 | serum | up-regulated | stage II and III/recurrence | [150] |
| miR-1260b | tissues | up-regulated | lymph node metastasis and venous invasion | [166] |
| miR-141 | plasma | up-regulated | advanced colon cancer | [167] |
| miR-429 | tissues | up-regulated | 5-FU treatment | [153] |
| miR-29a | tissues | up-regulated | stage II CRC/recurrence | [168] |
| miR-29a | serum | up-regulated | liver metastatic | [169] |
| miR-34a | plasma | up-regulated | adenoma | [170] |
| miR-106b | serum | up-regulated | lymph node metastasis and distant metastasis | [152] |
| miR-135b-5p | serum, stool | up-regulated | stage III and IV | [147] |
| miR-126 | serum | down-regulated | early-stage liver-metastatic | [171] |
| miR-429 | tissues | down-regulated | stage III and IV/lymphatic metastasis | [172] |
| miR-24, miR-320a, and miR-423-5p | plasma | down-regulated | postoperative metastasis | [159] |