Figure 3.

Modification circuits involving tRNA core modifications: (a) modification circuits identified in T. thermophilus ${\mathrm{tRNA}}^{\mathrm{Phe}}$ in response to temperature changes represented on a cloverleaf scheme [94,95,107]; (b) T-arm modification circuits identified in yeast ${\mathrm{tRNA}}^{\mathrm{Phe}}$ [69,70]; (c,d) modification circuits identified in E. coli ${\mathrm{tRNA}}^{\mathrm{Phe}}$ [109,110,111]; and (e) modification circuits identified in E. coli ${\mathrm{tRNA}}^{\mathrm{Asp}}$ [111]. Modifications are represented by colored circles (see the legend in the box for the corresponding colors). Arrows indicate stimulatory effects between modifications, and blunted lines indicate inhibitory effects between modifications.