Table 4.
Antimicrobial Activity of WG-1 against Pathogen Challenges Determined by Shake Flask and Biofilm Tests
| shake flask test | biofilm test | ||||
|---|---|---|---|---|---|
| pathogen/Gram (±)e | percent infectionsb (%) | log reductiona,c | % kill | log reductionc | % reduction |
| E. coli (G−) K-12 | 23.90 | 4.3B | >99.99 | d | |
| E. coli (G−) uropathogenic | 23.90 | >5B | >99.999 | 3.2 | 99.93 |
| C. albicans | 17.80 | >4B | >99.99 | 3.4 | 99.9 |
| E. faecalis (G+, E) | 11 | >5B | >99.999 | d | |
| P. aeruginosa (G–, E) | 10.3 | 0.8B | ~80 | 1.4 | 95.9 |
| K. pneumoniae (G–, E) | 10.1 | 5B | 99.999 | 2.9 | 99.9 |
| S. aureus (G+, E) | 1.6 | 0.9M9 | ~90 | 2.3 | 99.5 |
a
Superscripts indicate the test medium, both at pH ~7; B = PB; M9 = M9 medium.
b
Percent pathogens for UTIs vary in reviews. Those listed are from Infect. Control Hosp. Epidemiology, 2016, 37, 1288–130 and Nat Rev Microbiol. 2015, 13, 269–284.
c
Log reduction for C14–3 is based on growth for untreated Bardex all-silicone.
d
Not determined.
e
“ESKAPE” pathogens are designated “E” (see text).