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. 2024 Mar 15;25(6):3348. doi: 10.3390/ijms25063348

Table 2.

Anti-proliferative activities of 5c, 5h, 6c, and 6h against MDA-MB-231, MCF-7, and HepG2 cancer cell lines.

Compound IC50 (µM) 1
MDA-MB-231 MCF-7 HepG2
Normo Hypo Normo Hypo Normo Hypo
5c 48.10 ± 3.23 46.23 ± 3.93 34.33 ± 2.85 28.12 ± 1.72 61.36 ± 5.75 69.43 ± 5.16
5h 75.25 ± 6.81 81.2 ± 7.34 63.84 ± 5.57 57.43 ± 5.50 81.41 ± 7.03 80.41 ± 7.14
6c 56.34 ± 4.19 61.56 ± 5.13 50.44 ± 4.73 47.04 ± 4.01 68.78 ± 4.17 62.78 ± 5.52
6h 54.23 ± 4.87 50.35 ± 4.27 41.36 ± 2.22 30.31 ± 3.14 58.23 ± 5.45 54.33 ± 5.15
Staurosporine 10.30 ± 0.51 10.55 ± 0.84 7.81 ± 0.59 7.65 ± 0.73 18.71 ± 1.45 17.78 ± 0.97

1 IC50 values represent an average of at least three independent experiments.