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Schematic illustration showing functional interplay between histone, H2A.L.2, Transition proteins and Protamine during spermatogenesis in mice. N–terminal of H2A.L.2 allow the binding of RNA and it guides the histone variant to the heterochromatin’s nucleosome. Replacement of canonical H2A occurs and H2A.L.2 subsequently recruit transition proteins (TP) loading on nucleosome, and further drives TP-dependent protamine assembly and histone eviction to form mature spermatozoa.
