Figure 6.

Schematic illustration showing all the signaling pathways that are involved in drug resistance in cancer therapy when H2A.J is overexpressed. Increase in H2A.J regulates multiple significant signaling pathways including ERK5, TNF-α/NF-κB, PI3K/Akt, JAK /STAT, HIV Nef, IL-6/STAT and more (not listed all here). These pathways play different role and allow cancer cells to survive against different drug treatments through accelerating large amount of inflammatory responses, escaping CD8+ T cell activity and enhance their cell proliferation rate and cell growth.