Figure 4.

SF-based nanoparticles systems: (A) Non-MTX-loaded particles (1) and MTX-loaded Fe₃O₄-SF nanoparticles (2) (adapted from [129], Copyright 2015 Chen et al. This work is published by Dove Medical Press Limited); (B) MTX-loaded magnetic SF-NPs, cumulative permeation of MTX across the skin in the presence of pulsed, alternating magnetic field. @, #, and & indicate the statistical significant difference when compared with the stationary magnetic field, the alternating magnetic field, and the stationary/alternating magnetic field, respectively. p < 0.05. (reprinted from [129], Copyright 2015 Chen et al. This work is published by Dove Medical Press Limited); (C) fluorescence microscope image of a cross-section of the mouse skin after 6 h comparing the control rhodamine B solution (1,2) and the fluorescent SF-nanoparticles (3,4) (Adapted from [111], copyright 2018 Elsevier B.V.).