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. 2024 Mar 12;25(6):3229. doi: 10.3390/ijms25063229

Figure 4.

Figure 4

Effect of ripasudil on inflammation cytokines and chemokines. A cytometric bead array was used to detect the level of inflammation cytokines and chemokines in the supernatant of hTM cells cocultured with MT-2. Interleukin(IL)-8 decreased after treatment with 1, 10, and 100 μmol/L ripasudil (p = 0.0027, p = 0.0065, p = 0.0038, respectively). IL-6 and IL-10 decreased after treatment with 100 μmol/L ripasudil (p = 0.0080, p = 0.0091, respectively). IL-12 decreased after treatment with 10 and 100 μmol/L ripasudil (p = 0.0122, p = 0.0003, respectively). The levels of CXCL-9 and CXCL-10 did not statistically change after ripasudil treatment (*: p < 0.1; **: p < 0.01; ***: p < 0.001).