Skip to main content
. 2024 Mar 13;15(3):355. doi: 10.3390/genes15030355

Table 1.

Probands from ten unrelated families of Ashkenazi Jewish ancestry found to harbor the POT1 I78T variant.

Patient Sign in Family Tree Sex Current Age (yrs) Cancer (Age at Diagnosis) Cancer in Non-Genotyped Family Members (Number of Individuals)
1-II-1 M 67

  • Melanoma (40)

  • Melanoma (2)

  • Desmoid (1)
2-III-1 F 34

  • Melanoma (25)

  • Breast cancer (1)
3-II-1 F 68

  • Melanoma (58)

  • CLL (64)

  • Breast cancer (67)

  • Melanoma (1)

  • Breast cancer (1)

  • Uterine cancer (1)

  • Gastric cancer (1)
4-III-1 M 52

  • Colonic polyps (25)

  • Melanoma (35)

  • Desmoid (41)

  • CLL (2)

  • Colorectal cancer (1)

  • Polyposis (1)
5-III-1 F 75

  • PTC (40)

  • Soft tissue sarcoma (48)

  • Melanoma (54)

  • Breast cancer (54)

  • Ovarian Cancer (1)
6-III-1 F 51

  • Melanoma (35)

  • Breast cancer (44)

  • Melanoma (3)

  • Colorectal cancer (1)
7-II-1 F 68

  • Melanoma (45)

  • Oligodendroglioma (60)

  • Liposarcoma (65)

  • Desmoid tumor (66)
8-III-1
8-III-2 		F
F		 61
64

  • Desmoid tumor (60)

  • Breast cancer (51)

  • Melanoma (51)

  • Neuroblastoma (1)

  • Glioma (1)
9-III-1 F 45

  • PTC (31)

  • Breast cancer (44)

  • Melanoma (1)
10-II-1 M 67

  • Colonic polyps (59)

  • Adrenal pheochromocytoma (59)

  • Transitional cell carcinoma (60)

  • Neuroendocrine tumor (60)

  • Lung cancer (62)

  • PTC (63)

  • Melanoma (63)

  • Breast cancer (1)

  • Colorectal cancer (1)

  • Sarcoma (1)

Abbreviations: CLL: chronic lymphocytic leukemia, PTC: papillary thyroid cancer.