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. 2024 Mar 16;25(6):3379. doi: 10.3390/ijms25063379

Figure 5.

Figure 5

Transmigration activity of the BC cell lines MCF-7 (control), BT-474 (Her2+), and MDA-MB-231 (triple-negative (TN)) after treatment of cEND and hCMEC/D3 with E2 and DPN in the concentrations 10−12, 10−10, and 10−8 M in comparison to the untreated control. (a) cEND + MCF-7: transmigration of MCF-7 cells in the in vitro model with cEND showed no significant changes; (b) cEND + BT-474: transmigration of BT-474 cells in the cEND cell culture model was reduced significantly by treatment with DPN (10−12 M, 10−10 M); (c) cEND + MDA-MB-231: transmigration of MDA-MB-231 cells over the monolayer of cEND cells was significantly increased by E2 (10−10 M); (d) hCMEC/D3 + MCF-7: transmigration of MCF-7 cells in the in vitro model with hCMEC/D3 showed no significant changes; (e) hCMEC/D3 + BT-474: transmigration of BT-474 cells in the hCMEC/D3 cell culture model was reduced significantly by treatment with DPN (10−10 M); (f) hCMEC/D3 + MDA-MB-231: transmigration of MDA-MB-231 cells over the monolayer of hCMEC/D3 cells did not differ significantly. All means ± SD; n = 21; D’Agostino and Pearson test (α = 0.05): passed Dunn’s post hoc multiple comparisons test; 0.1234 (ns), 0.0332 (*), 0.0021 (**), 0.0002 (***), <0.0001 (****).