Table 4.
Results from the physiological stimulation experiment showing the effects of differentiation (D) of cancer (C) and endothelial (E) cells with E2 without subsequent treatment (T) (left column; condition 2), differentiation of endothelial cells only followed by treatment of cancer and endothelial cells with DPN (middle column; condition 3), and differentiation with E2 followed by treatment with DPN of cancer and endothelial cells (right column; condition 4) on the transmigration activity of the BC cell lines MCF-7 (control), BT-474 (Her2+), and MDA-MB-231 (TN) in the murine (cEND) and human (hCMEC/D3) brain endothelial cell barrier model.
| Endothelial Cell Lines | BC Cell Lines | D: E2 (C+E) T: without (2) |
D: E2 (E) T: DPN (C+E) (3) |
D: E2 (C+E) T: DPN (C+E) (4) |
|---|---|---|---|---|
| cEND | MCF-7 | + | − | ++ |
| BT-474 | ||||
| MDA-MB-231 | + | −− | + | |
| hCMEC/D3 | MCF-7 | |||
| BT-474 | ||||
| MDA-MB-231 | +++ | −−− | ++ |