Table 1.
Candidate genes involved in meiosis, DNA replication, and repair implicated in premature ovarian insufficiency. AR: Autosomal recessive variants have been reported. AD: Autosomal dominant variants have been reported.
| Gene | Inheritance | Reference |
|---|---|---|
| MCM 8 | AR, AD | [21,28,29,30,31,32,33] |
| MCM 9 | AR, AD | [30,34,35,36,37,38] |
| REC8 | AR, AD | [21,39] |
| HROB (C18orf53) | AR | [21,27] |
| NUP107 | AR | [21,40] |
| STAG3 | AR | [21,41] |
| HFM1 | AR | [21,42] |
| POF1B | AR, AD | [21,43,44] |
| SWI5 | AR | [27] |
| HELQ | AD, AR | [25,27,45] |
| MND1 | AR | [46] |
| PSMC3IP | AR | [47,48] |
| MSH4 | AR | [27,49] |
| MSH5 | AR, AD | [50,51] |
| MSH6 | - | [45] |
| CSB-PGBD3 | AD | [52] |
| ATM | AD | [27] |
| PRIM1 | - | [25] |
| DMC1 | AR | [53,54,55] |
| MEIOB | AR | [56,57] |
| SYCP2L | AR | [58] |
| SYCE1 | AR | [59] |
| HSF2BP | AR | [60,61] |
| TP63 | AD | [62,63] |
| ZSWIM7 | AR | [64,65] |
| FANCM | AR | [27,66,67] |
| FANCL | AD | [68] |
| FANCA | AD | [69] |
| FANCU (XRCC2) | AR | [70] |
| FANCI | - | [25] |
| BRCA1 (FANCS) | - | [45] |
| BRCA2 (FANCD1) | AR | [27] |
| SMC1B | AD | [39] |
| SGO2 | AR | [71] |
| SPIDR | AR | [27,72] |
| EXO1 | AD | [25,73] |
| RAD51 | AD | [73] |
| WDR62 | AD | [74] |
| NBN | AR | [75] |
| UIMC1 | - | [25] |
| ERCC6 | AD | [27] |
| LLGL1 | AD | [45] |
| BOD1L1 | AD | [45] |