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. Author manuscript; available in PMC: 2024 Mar 27.
Published in final edited form as: Exp Eye Res. 2022 Oct 4;225:109273. doi: 10.1016/j.exer.2022.109273

Figure 4.

Figure 4.

Induction of elevated IOP by microbead injection. A-B, mean IOP in C57bl/6 mice was not affected by PLX5622. Saline-injected mice on the control diet (light green) and the depletion diet (dark green) showed similar mean and cumulative IOPs. Mean and cumulative IOPs were significantly higher in microbead injected mice, both on the control diet (light red) and the PLX5622 diet (dark red). C, 4 weeks after microbead injection, the pattern ERG amplitude decreased, but there was no significant difference between mice on the control and the depletion diet. D, visual acuity (measured by observation of the oculomotor reflex) decreased in microbead-injected eyes compared to the saline-injected control group, but there was no difference between mice on the control diet and the depletion diet.