Table 1.

Gene ontology results generated by Enrichr. This table shows the top five enriched ontology terms (Biological Processes, Molecular Function, and Cellular Component) generated using the downregulated genes (619 genes) found in MHS muscle. Ontology terms are displayed in order of adjusted p-value (significance defined by p-value < 0.05).

MHN vs. MHS (Downregulated Genes) Gene Ontology Results
Biological Processes	p-Value	Adjusted p-Value	Odds Ratio	Combined Score
Aerobic electron transport chain (GO:0019646)	3.03 × 10−22	5.64 × 10−19	20.33	1007.15
Mitochondrial ATP synthesis coupled electron transport (GO:0042775)	4.66 × 10−22	5.64 × 10−19	19.87	976.20
Mitochondrial respiratory chain complex I assembly (GO:0032981)	3.23 × 10−14	1.96 × 10−11	15.27	474.21
NADH dehydrogenase complex assembly (GO:0010257)	3.23 × 10−14	1.96 × 10−11	15.27	474.21
Mitochondrial respiratory chain complex assembly (GO:0033108)	1.27 × 10−13	6.17 × 10−11	10.36	307.73
Molecular function	p -value	Adjusted p-value	Odds Ratio	Combined score
Oxidoreduction-driven active transmembrane transporter activity (GO:0015453)	1.35 × 10−20	6.05 × 10−18	22.50	1029.19
Proton transmembrane transporter activity (GO:0015078)	6.38 × 10−11	1.43 × 10−8	16.20	380.39
NADH dehydrogenase (quinone) activity (GO:0050136)	1.71 × 10−10	1.91 × 10−8	17.53	394.25
NADH dehydrogenase (ubiquinone) activity (GO:0008137)	1.71 × 10−10	1.91 × 10−8	17.53	394.25
Active ion transmembrane transporter activity (GO:0022853)	1.88 × 10−9	1.68 × 10−7	13.44	269.96
Cellular component	p -value	Adjusted p-value	Odds Ratio	Combined score
Mitochondrial inner membrane (GO:0005743)	4.55 × 10−42	1.06 × 10−39	10.42	991.95
Mitochondrial membrane (GO:0031966)	8.20 × 10−42	1.06 × 10−39	8.22	777.65
Organelle inner membrane (GO:0019866)	1.97 × 10−38	1.70 × 10−36	9.35	811.84
Mitochondrial matrix (GO:0005759)	2.17 × 10−18	1.40 × 10−16	5.51	223.92
Mitochondrial respiratory chain complex I (GO:0005747)	4.31 × 10−13	1.86 × 10−11	18.76	534.17