Table 2.
General linear model (GLM) repeated measurements ANOVA (RM-ANOVA) and two-way ANOVA analyses of the effects of natural autoantibodies and natural autoantibody changes on 0–12 month changes in other parameters.
| Full (RA + AS) Cohort | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| RM-ANOVA | Two-Way ANOVA | ||||||||
| Dependent Variable | Effect | F | Partial η2 | p | Dependent Variable | Effect | F | Partial η2 | p |
| CRP (0–12) | CS IgM-0 | 4.885 | 0.126 | 0.010 | CRP (0–12) | CS IgM (0–12) | 20.980 | 0.375 | <0.001 |
| FMD (0–12) | TOPO-F4 IgG-0 | 3.617 | 0.096 | 0.032 | CS IgG (0–12) | 10.186 | 0.225 | 0.003 | |
| TOPO-F4 IgM (0–12) |
16.208 | 0.317 | <0.001 | ||||||
| DAS28-CRP/ BASDAI (0–12) |
CS IgM (0–12) | 2.013 | 0.364 | <0.001 | |||||
| CS IgG (0–12) | 6.458 | 0.156 | 0.016 | ||||||
| TOPO-F4 IgM (0–12) | 7.227 | 0.171 | 0.011 | ||||||
| FMD (0–12) | CS IgM (0–12) | 18.315 | 0.344 | <0.001 | |||||
| PWV (0–12) | CS IgM (0–12) | 19.252 | 0.355 | <0.001 | |||||
| CS IgG (0–12) | 5.119 | 0.128 | 0.030 | ||||||
| TOPO-F4 IgM (0–12) | 5.120 | 0.128 | 0.030 | ||||||
| RA subset | |||||||||
| RM-ANOVA | Two-way ANOVA | ||||||||
| Dependent variable | Effect | F | partial η2 | p | Dependent variable | Effect | F | partial η2 | p |
| CRP (0–12) | CS IgM (0–12) | 12.277 | 0.393 | 0.002 | |||||
| CS IgG (0–12) | 4.673 | 0.197 | 0.044 | ||||||
| TOPO-F4 IgM (0–12) | 6.903 | 0.267 | 0.017 | ||||||
| DAS28-CRP (0–12) | CS IgM (0–12) | 11.941 | 0.986 | 0.003 | |||||
| AS subset | |||||||||
| RM-ANOVA | Two-way ANOVA | ||||||||
| Dependent variable | Effect | F | partial η2 | p | Dependent variable | Effect | F | partial η2 | p |
| BASDAI (0–12) |
CS IgM-0 | 3.911 | 0.376 | 0.047 | CRP (0–12) | CS IgM (0–12) | 8.263 | 0.355 | 0.012 |
| BASDAI (0–12) | CS IgM (0–12) | 7.640 | 0.337 | 0.014 | |||||
| ccIMT (0–12) | CS IgM (0–12) | 15.000 | 0.318 | 0.018 | |||||
| PWV (0–12) | CS IgM (0–12) | 7.074 | 0.320 | 0.018 | |||||
The numbers 0, 6, and 12 represent baseline, 6 months, and 12 months, respectively. Abbreviations: ANOVA, analysis of variance; AS, ankylosing spondylitis; BASDAI, Bath Ankylosing Spondylitis Disease Activity Index; ccIMT, common carotid intima-media thickness; CRP, C-reactive protein; CS, citrate synthase; DAS28-CRP, 28-joint disease activity score; FMD, flow-mediated vasodilation; GLM, general linear model; Ig, immunoglobulin; PWV, pulse-wave velocity; RA, rheumatoid arthritis; RM-ANOVA, repeated measurements ANOVA; TOPO-F4, topoisomerase I fragment 4.